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Saturday, July 18, 2020 | History

4 edition of The efficacy and safety of amlodipine in pediatric patients found in the catalog.

The efficacy and safety of amlodipine in pediatric patients

John W. Rogan

The efficacy and safety of amlodipine in pediatric patients

by John W. Rogan

  • 11 Want to read
  • 39 Currently reading

Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .
Written in English


Edition Notes

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches.
ID Numbers
Open LibraryOL18869577M
ISBN 100612293289
OCLC/WorldCa46585838

I am honored and grateful to be chosen as the Richard Helms Award recipient. This recognition has a special meaning since it carries the name of an individual who has contributed so much to pediatric pharmacy through innovative practice, education and research, especially in the area of parenteral nutrition, as well as mentoring numerous outstanding students, residents, fellows and. Amlodipine was also well tolerated by patients with mild hepatic impairment, but the dose required to achieve efficacy will probably be lower than for other patients. lusion, the good safety profile of amlodipine, the relative lack of adverse events commonly encountered with other classes of cardiovascular agents, and the relative lack of Cited by:

Uses for Lotrel. Amlodipine and benazepril is a combination of medicines that are used to treat high blood pressure (hypertension). have not been performed on the relationship of age to the effects of amlodipine and benazepril combination in the pediatric population. Safety and efficacy have not been established. elderly patients are / Pediatric. Appropriate studies have not been performed on the relationship of age to the effects of aliskiren and amlodipine combination in the pediatric population. Safety and efficacy have not been established. Geriatric.

  Comparative efficacy and safety profile of amlodipine 5 mg/losartan 50 mg fixed-dose combination and amlodipine 10 mg monotherapy in hypertensive patients who respond poorly to amlodipine 5 mg monotherapy: an 8-week, multicenter, randomized, double-blind . An 8 Weeks, Multi-Center, Randomized, Double Blinded, Comparative Phase 3 Clinical Trial to Assess the Efficacy and Safety of S-Amlodipine Gentisate Compared to Amlodipine Besylate in Patients With Mild-to-Moderate Hypertension: Study Start Date: January Study Completion Date: February


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The efficacy and safety of amlodipine in pediatric patients by John W. Rogan Download PDF EPUB FB2

We designed a study to determine the efficacy and safety of amlodipine given once daily in the pediatric population. Twenty-one patients (mean age years) with either essential (n=) or renal (n=5) hypertension, and newly diagnosed (n=15) or poorly controlled or intolerant on existing antihypertensive therapy (n=6), were included.

Patients received amlodipine once daily at a starting Cited by: Most antihypertensive agents used in adults are also administered to pediatric patients. Yet. there exists few data regarding the efficacy and long- term safety in this cohort'.

Calcium antagonists are in widespread use in pediatric patients because of the lack of side effects at therapeutic : John W. Rogan. We designed a study to determine the efficacy and safety of amlodipine given once daily in the pediatric population.

Twenty-one patients (mean age years) with either essential (n=) or renal (n=5) hypertension, and newly diagnosed (n=15) or poorly controlled or intolerant on existing antihypertensive therapy (n=6), were by: AbstractWe designed a study to determine the efficacy and safety of amlodipine given once daily in the pediatric population.

Twenty-one patients (mean age years) with either essential (n=) or renal (n=5) hypertension, and newly diagnosed (n=15) or poorly controlled or intolerant on existing antihypertensive therapy (n=6), were by:   Conclusions: Amlodipine was shown to be a well tolerated and effective drug in one in three patients, and achieved the therapeutic goal in a higher proportion of patients at specialised-care centres compared with those in primary care, and in those receiving combined therapy compared with Cited by: 8.

In patients with severe hypotension, amlodipine can result in a further drop in blood pressure, hypoperfusion to vital organs, and syncope. Patients who have heart failure may experience pulmonary edema, shortness of breath, and dyspnea with amlodipine.

[16]. The Pediatric use of Amlodipine in the Treatment of Hypertension (PATH) 1 study was sponsored by Pfizer Pharmaceuticals and conducted at 49 centers in the United States, Canada, Argentina, and Brazil. Data collection and site monitoring were conducted by Cited by:   The principal aim of this study was to evaluate the safety and efficacy of amlodipine in two cohorts of patients, one of which was attended at primary-care and the.

The efficacy of amlodipine monotherapy in reducing blood pressure is well established in a number of populations, including patients aged ≥65 years, 25 pediatric patients, 26 patients treated at primary and also specialized care centers, 27 and patients of different ethnic by: 5.

Safety profiles did not differ between groups, but cough was more common in the combination group (% vs. 0%; p = ) Langdon et al 11 undertook a study to assess the efficacy and tolerability of Amlodipine in elderly patients with mild to moderate hypertension (diastolic blood pressure 95 to mmHg).

This was an open-label. Pediatric use of amlodipine has previously been reported,19, 20, 21 but prior reports have been limited by small patient numbers, homogeneous patient populations, or lack of efficacy data.

In addition, previous investigators have responded to amlodipine adverse effects by discontinuing therapy, 20, 21 an approach that in our experience was Cited by:   Usual Pediatric Dose for Hypertension.

6 to 17 years: Maintenance dose: to 5 mg orally once a day-Maximum dose: 5 mg/day Comments: Doses higher than 5 mg have not been studied in pediatric patients. The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days/   Patients receive more than one anti-hypertensive medicine.

Patients with seconder hypertension. Patients with severe hypertension, myocardial infarction, NYHA stage cardiac insufficiency, history of cerebrovascular disease, past ischemic attack, encephalopathy. From these findings, amlodipine ODT was confirmed to have an efficacy at clinical sites identical to that of amlodipine formulations from other companies.[14,15] It was also confirmed to have lowered blood pressure relative to that at treatment initiation, without further increases in the heart rate.

Therefore, amlodipine ODT was confirmed as an easy-to-use antihypertensive that moderately lowered blood Cited by: 8.

Before Using. Drug information provided by: have not been performed on the relationship of age to the effects of amlodipine and benazepril combination in the pediatric population.

Safety and efficacy have not been established. which may require an adjustment in the dose for patients receiving amlodipine and benazepril combination. Efficacy/Safety of Amlodipine Plus Losartan Versus Amlodipine in Patients With Stage 2 Hypertension.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Effects were similar in black patients and in white patients.

Pediatric Patients Two hundred sixty-eight hypertensive patients aged 6 to 17 years were randomized first to NORVASC or 5 mg once daily for 4 weeks and then randomized again to the same dose or to placebo for another 4 weeks. mg (Norvasc, generic) 5mg (Norvasc, generic) 10mg (Norvasc, generic) oral suspension.

1mg/mL (Katerzia) Safety and efficacy not established. Indicated for hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.

Felodipine is one of the most vascular selective of the available CCBs and it has no negative inotropic effects at clinically administered doses. Focus of this review is to comprehensively summarize the pharmacokinetics, efficacy, safety and tolerability of by: 5.

Not known whether amlodipine is distributed into milk; manufacturer recommends discontinuance of nursing if amlodipine is used. Pediatric Use. Safety and efficacy of amlodipine in children Efficacy of amlodipine –5 mg daily for treatment of hypertension established in pediatric patients 6–17 years of /.

To our knowledge, this is the largest cohort of pediatric amlodipine ingestions reported to date. The only other report to examine pediatric calcium channel blocker poisoning was published by Belson et al.

in That study included patients, 39 of whom had ingested by: Pediatric. Appropriate studies have not been performed on the relationship of age to the effects of perindopril and amlodipine combination in the pediatric population.

Safety and efficacy have not been established. Geriatric.Aim. To study efficacy and safety of calcium channel blocker, S-amlodipine, in combination with β-blocker, atenolol, in patients with arterial hypertension (HT) degree com- pared to fixed.